Hedgehog pathway antagonists and methods of use
The present disclosure provides for compounds, pharmaceutical preparations, kits and methods for the inhibition of the Hh pathway and the alleviation of cancer and developmental disorders associated...
View ArticleGenomic editing of neurodevelopmental genes in animals
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with neurodevelopmental disorders. In particular,...
View ArticleAnti-il-17 antibodies
Anti-IL-17 antibodies are identified that are characterized as having a high affinity and slow off rate for human IL-17. The antibodies of the invention may be chimeric, humanized or fully human...
View ArticleSonic hedgehog modulators
The present invention relates to relates to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, syntheses thereof, and intermediates thereto. Such small molecule modulators...
View ArticleRna molecules and uses thereof
The present invention relates to substantially single-stranded isolated RNA molecules comprising 18 to 19 contiguous nucleotides that corresponds to a non-protein-coding genomic DNA sequence located...
View ArticleHerbal-based compositions for alleviating symptoms associated with autism
Aspects of the invention relate to compositions comprising passiflora extracts that may improve neurological and behavioral symptoms associated with Pervasive Developmental Disorders....
View ArticleSmall molecule pak inhibitors
The present invention provides methods for treating fragile X syndrome and/or other neurodevelopmental disorders by administering small molecule p21-activated kinase (PAK) inhibitors to a patient...
View ArticleMaterial and methods for treating developmental disorders including comorbid...
Subjects who were diagnosed with either comorbid or idiopathic autism were treated with acamprosate. Patients generally showed marked improvements in primary outcomes as assessed using, for example,...
View ArticleMethod and composition for modulating canonical wnt pathway using folate and...
The canonical Wnt signaling pathway is implicated in many disorders including neural tube defects, limb malformations, and heart defects, developmental disorders associated with alcohol exposure...
View ArticleMedical foods for the treatment of developmentally-based neuropsychiatric...
Describe herein are medical foods, pharmaceutical compositions, methods of compounding them, and method of using them for the treatment of developmentally-based neuropsychiatric disorders including...
View ArticleMethods and systems for preparation of treatment plans
A program module is configured with sub-modules for child development assessment, presentation of progress charts and development of individualized treatment plans. An assessment sub-module includes...
View ArticleApparatus and method for voice based diagnostic support
An apparatus () is disclosed adapted to diagnose disorders related to the brain of a subject. The apparatus comprises a display () for presenting stimuli to said subject, a microphone () for...
View ArticleHedgehog pathway antagonists and methods of use
The present disclosure provides for compounds, pharmaceutical preparations, kits and methods for the inhibition of the Hh pathway and the alleviation of cancer and developmental disorders associated...
View ArticleDiagnostic methods for the detection of risk of neurodevelopmental disorders
The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural...
View ArticleTreatment of pervasive developmental disorders with tocotrienols or...
Methods of treating or suppressing Pervasive Developmental Disorders (PDDs) including; Autistic Disorder, Asperger's Disorder, Childhood Disintegrative Disorder (CDD), Rett's Disorder, and PDD-Not...
View Article4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial...
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, and...
View ArticleSystems and methods for remote access to treatment plans
Computer-based methods and systems for providing individuals access to automatically generated and individualized ABA-based programs of instruction based on the needs of children with developmental...
View ArticleImage analysis for determining characteristics of humans
Systems and methods are disclosed for predicting one or more characteristics of a animal by applying computational methods to image(s) of the animal to generate one or more metrics indicative of the...
View ArticleImage analysis for determining characteristics of animals
Systems and methods are disclosed for predicting one or more characteristics of a animal by applying computational methods to image(s) of the animal to generate one or more metrics indicative of the...
View ArticleTreatment of pervasive developmental disorders with redox-active therapeutics
Methods of treating or suppressing pervasive developmental disorders (PDDs) including; autistic disorder, Asperger's syndrome, childhood disintegrative disorder (CDD), Rett's disorder, and PDD-not...
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